The two Manchester clubs - Manchester City and local rivals Manchester United - will take part in their fifth Champions League game of the season, this evening.
It is almost a full gone conclusion that both will qualify for the knock-out stages. City have already qualified, whilst United will book their place with a win over Bayer Leverkusen.
The Red Devils, and their opponents for tonight, could both qualify if they draw and Real Sociedad defeat Shakthar Donetsk in Group A's other game.
Although both teams have looked shakey in the domestic league this season, they have performed impressively in the Champions League. It is the first time in their history that City have qualified for the knock-out stages of the UCL.
Manchester City play hosts to Viktoria Plzen, after humiliating Tottenham Hotspur 6 - 0 at the weekend. Joe Hart will return to the starting XI for the first time in over a month.
David Moyes' men are away at the BayArena. They will line-up against the German team without injured Nemanja Vidic and Robin van Persie. Marouane Fellaini also misses the game through suspension.
We predict it will be a comfortable night for City, but their neighbours could find themselves in a sticky situation in Germany.